Chemotherapy may cause ulcerative colitis, but it is relatively rare. Chemotherapy will damage the normal cells of the human body, and at the same time cause irritation and damage to the mucosa of the digestive tract, most patients are regurgitation, acid reflux, as well as loss of appetite, headache and other adverse reactions, but some patients in the role of chemotherapeutic drugs will be congested mucous membrane ulceration and ultimately lead to ulcerative colitis, but it is relatively rare, the incidence of a relatively low. Chemotherapy-induced ulcerative colitis should be treated with medication under the guidance of a doctor. Mild patients are usually treated with antibiotics and mucosal protectants for a period of time before they can recover and improve. If the condition is relatively serious and accompanied by bacterial flora disorders, glucocorticoid medication should be used. During this period, patients need to keep drinking more water, light diet habits, if necessary, can suspend chemotherapy treatment, and wait for the body to recover to continue treatment.