There is no effective drug treatment for esophageal papilloma, and the treatment is based on resection of the tumor, endoscopic resection is preferred. 1. Interferon: it is suitable for malignant tumors, viral diseases and so on. It should be used with caution in allergy, severe cardiac, hepatic or renal insufficiency, bone marrow suppression, pregnant women, lactating women and patients under 18 years old. The main adverse reactions are flu-like symptoms, i.e. chills, fever and malaise. 2. Surgical treatment: the treatment of esophageal papilloma is mainly based on surgical resection, smaller tumors can be removed with the assistance of endoscopy, and laryngoscopic application of CO2 laser to remove the tumor is the most effective treatment for laryngeal papilloma. It is recommended to go to the hospital in time to give targeted treatment or therapy.