Alkaline phosphatase is found mainly in the liver, bones, kidneys, small intestine and placenta, and is one of the indicators of liver disease screening. High alkaline phosphatase can be seen in physiologic conditions, which are generally not serious, and in hepatobiliary diseases that involve the liver parenchyma cells, which are relatively serious. 1. Physiological conditions: growing children, late pregnancy, after eating a high-fat diet. 2. Hepatobiliary diseases: such as viral hepatitis, alcoholic cirrhosis with mild elevation. When there are obstructive diseases in the intra- and extrahepatic bile ducts, such as gallbladder stones, pancreatic head cancer with bile duct obstruction, alkaline phosphatase will be significantly elevated, accompanied by elevated serum bilirubin. 3. Others: such as fracture healing period, severe anemia, malnutrition, etc., there are different degrees of elevation. For those with high alkaline phosphatase, it is recommended to consult a gastroenterologist, who will provide diagnosis and treatment after comprehensive evaluation.