Decreased total protein and albumin in the blood can lead to lower extremity edema. Hypoproteinemia, i.e., low albumin in the blood, is most commonly seen in malnutrition due to wasting diseases, such as malignant tumors, tuberculosis, and other diseases, where prolonged consumption of protein leads to hypoproteinemia and, in severe cases, generalized edema. The main reason is that the albumin is reduced, the colloid osmotic pressure in the blood is low, the water penetrates into the tissue interstitial space, tissue edema occurs, and the lower limbs are more obvious due to gravity. At this time need to strengthen the nutritional intake, such as meat, eggs and milk intake, if necessary, protein powder, nutrient intake, such as severe hypoproteinemia need to be intravenous infusion of serum albumin, etc., the specific need to comply with the doctor’s instructions for treatment. In addition, other common causes of lower extremity edema include the following. 1. Heart failure: right heart failure and total heart failure cause poor circulation, which leads to lower limb edema. 2. Renal insufficiency: When renal insufficiency occurs, sodium retention can also lead to lower limb edema. 3. Thyroid disorders: hyaluronidase inhibition in hypothyroidism can also lead to lower limb edema. Note: When you find low albumin and lower limb edema, you need to consult a doctor in time to find the cause of treatment.