Occasional irregularities in work and rest do not usually have a significant effect. However, prolonged irregularity in work and rest may have adverse effects on the endocrine system, nervous system, digestive system, etc. 1. Nervous system: long-term irregular work and rest may lead to autonomic nervous system disorders, prone to neurasthenia, can be manifested as irritability, irritability, fatigue, memory loss and other hazards. 2. Endocrine system: irregular work and rest will lead to the body’s normal biological clock is disrupted, the body of endocrine disorders, skin dark yellow, dark circles under the eyes. Women may also experience irregular menstruation and other symptoms. 3. Digestive system: long-term irregular work and rest may also affect the dietary laws. This can cause gastrointestinal dysfunction, slow gastric motility, indigestion, loss of appetite and other symptoms. Daily life to develop a good work and rest habits, but also can be appropriate to participate in outdoor exercise, on time and according to the amount of food, do not overeat. If you feel unwell due to irregular work and rest, it is recommended that you seek medical attention in a timely manner.