Glutamine transpeptidase (GATP) and glutamine aminotransferase (GAT) are both commonly used clinical indicators of liver function, and the causes of their elevation can be categorized into liver diseases and non-liver diseases. 1. Liver diseases: When liver diseases such as acute and chronic hepatitis, cirrhosis, alcoholic liver disease, etc. occur, the liver cells will be damaged, which will cause a certain degree of elevation of glutamine transpeptidase and glutamine aminotransferase. 2. Non-liver diseases: Acute pancreatitis, biliary tract infections and other non-liver diseases can also have elevated levels of both enzymes, suggesting liver cell destruction. Some external factors, such as staying up late and drinking alcohol, can also lead to transient elevation of AST, which generally does not require special treatment. In addition, some drugs such as phenobarbital can cause some liver damage, and long-term use may lead to elevated glutamine transpeptidase. When glutamine transpeptidase and glutamine aminotransferase are elevated, you should consult your doctor for further examination to determine the cause of the elevation and active treatment.