Diagnosed with atypical chronic lymphocytic leukemia, timely targeted treatment should be carried out, common treatment methods include chemotherapy, hematopoietic stem cell transplantation, and so on, and different treatments should be adopted according to the different conditions of the patients. 1. Chemotherapy is a common treatment for atypical chronic lymphocytic leukemia, which mainly aims to remove leukemia cell clones and rebuild the normal hematopoietic function of bone marrow. Commonly used medicines include alkylating agents such as nitrogen mustard phenylbutyrate, cyclophosphamide, etc., and combined with purine analogs such as fludarabine and glucocorticosteroids (dexamethasone) and other medicines, which has a better therapeutic effect. 2. Hematopoietic stem cell transplantation is mainly to rebuild the normal hematopoietic and immune system of patients through intravenous infusion of hematopoietic stem cells to treat leukemia. The main sources of hematopoietic stem cells are umbilical cord blood, bone marrow, etc. Hematopoietic stem cells can cure leukemia in general, but it is difficult to match the type, the cost is high, and there is a certain recurrence rate. It is recommended that when suffering from atypical chronic lymphocytic leukemia, one should go to the hospital in time and actively cooperate with the doctor for treatment.