The differences between liraglutide and simethicone are different specifications, different indications, different adverse reactions, different contraindications, etc. 1. Different specifications: Liraglutide is 3ml:18mg, and simethicone is 1.34mg/ml. 2. Different indications: Liraglutide is mainly applied to adult type 2 diabetes mellitus patients to control blood glucose, in the metformin or sulfonylurea maximum tolerable dose of treatment of blood glucose is still ineffective patients, can be combined with metformin or sulfonylurea drugs. Simeglutide is indicated for the reduction of major adverse cardiovascular events, such as cardiovascular death, in adult patients with concomitant cardiovascular disease and type 2 diabetes mellitus. 3. Different adverse reactions: some patients may experience headache, dizziness, dyspepsia, flatulence, abdominal distension and other adverse reactions when using liraglutide; in the process of using simethicone, nausea, diarrhea, vomiting and other symptoms, which need to be stopped immediately. 4. Different contraindications: the use of liraglutide is prohibited for those who are allergic to the active ingredient of liraglutide or any other excipients in the drug; the use of simepaglutide is prohibited for those who are allergic to simepaglutide or any other excipients in the drug. It is recommended that patients under the guidance of a doctor, strictly comply with medical advice to use drugs, not blindly use drugs or unauthorized changes in drug dosage, so as not to cause adverse effects on the body, triggering other diseases.