Gastroscopic manifestations of cardia cancer include plaque-like, erosion-like, localized mucosal hyperplasia nodule-like, cauliflower-like mass and other manifestations. Different stages of cardia cancer lead to differences in gastroscopy performance. For early stage pancreatic cancer patients, gastroscopy may find that the lesions are relatively small in size and appear as indurated lesions, but some patients may also show such manifestations as plaque-like, vesicular, local mucosal hyperplasia or nodular. For early stage cardia cancer patients, it is easy to be missed and misdiagnosed, and it is necessary to cooperate with tumor marker examination to make a clear diagnosis when necessary. With the gradual development of the disease, patients with cardia cancer in the middle and late stages may find cauliflower-like lumps or even masses in gastroscopy, and there may be congestion and edema in the mucosa and narrowing of the lumen of the cardia. The final diagnosis of cardia cancer needs to be based on endoscopic pathological biopsy. If cardia cancer is diagnosed, it can be treated by endoscopic surgical resection or surgery in the early stage, and if necessary, it needs to be treated with chemotherapy and targeted therapy.