The dosage of extended-release metformin is 500mg to 2000mg/day. The specific dosage should follow the physician’s instruction. Extended-release metformin, known as metformin hydrochloride extended-release tablets or extended-release capsules, is a hypoglycemic drug. The drug is usually started with a total dose of 500mg/day, and the dosage is adjusted according to the blood glucose level, with the maximum dosage being a total dose of 2000mg/day. Specific dosage and frequency of use should be directed by a physician. This drug may cause nausea, gastric distension, abdominal discomfort, fatigue, dizziness, palpitations, muscle pain and other adverse reactions, and is contraindicated in patients with diabetic ketoacidosis, renal insufficiency, heart failure, acute myocardial infarction, allergy, severe infections. During the use of medication, pay attention to monitoring blood glucose and observe whether there are symptoms of discomfort, if there are obvious fluctuations in blood glucose or discomfort need to immediately stop the drug and seek medical attention. Patients who need to take metformin hydrochloride extended-release tablets or extended-release capsules should be under the guidance of a doctor, do not self-medication.