High uric acid may cause knee pain, possibly due to the deposition of urate crystals in the joints leading to joint inflammation. In clinical terms, hyperuricemia is defined as two fasting blood uric acid levels greater than 420 μmol/L on non-same days. Hyperuricemia may have no obvious symptoms in the early stages of the disease, and as the disease progresses urate crystals deposited in the joints will appear joint pain, redness and swelling and other symptoms, often involving the first metatarsophalangeal joints, knee joints, wrist joints and so on. Therefore, high uric acid may cause knee pain. In addition, hyperuricemia affects kidney function, leading to kidney stones, and increases the risk of diseases such as atherosclerosis, hypertension, chronic heart disease, and diabetes. For patients with hyperuricemia, it is recommended to eat a low purine diet, avoid alcohol, monitor uric acid levels regularly, and use medications such as Benzbromarone as prescribed by your doctor when necessary. High uric acid may cause knee pain, but diseases such as osteoarthritis may also cause knee pain. It is recommended that patients seek timely medical attention, have a comprehensive assessment by a specialized doctor, and follow the doctor’s instructions for treatment.