The possibility of preventive injections for children with epilepsy is a question often asked by parents. Preventive injections are equally important to prevent infectious diseases in children with epilepsy. However, unfortunately there are no guidelines that simply answer whether prophylactic vaccination is possible in epilepsy or not. In general, vaccination can be deferred during periods of frequent seizures and then given after 1-2 years of seizure stabilization or control. At present, there is a strict quality control and audit system for vaccines in China, and the safety of vaccines is guaranteed. Of course, it is possible to have some kind of reaction after vaccination (e.g. DPT, MMR, BSE), and it is not recommended for those who are contraindicated in the instructions for vaccine use. There are many vaccination reactions, including convulsions, and the incidence of post-vaccination allergic encephalopathy is very small, ranging from 1 in 300,000 to 1 million. Immunodeficient individuals and infants with severe myoclonic epilepsy (Dravet syndrome) are prone to post-vaccination reactions and should not be vaccinated. For children with certain congenital defects that have not yet developed before vaccination (such as organic aciduria, mitochondrial disease, fatty acid metabolism disorders, urea cycle disorders, etc.), vaccination may induce convulsions, unpredictable accidents, or even sudden death, which is easily misinterpreted by parents as “vaccination has made their children stupid or killed”. In fact, these diseases can start acutely under stressful conditions such as fever, fatigue, drugs, starvation, and disease, and they are usually caused by genetic or inherent defects. Therefore, parents must weigh the pros and cons themselves, make a choice whether to agree to vaccination or not, and have the right understanding and attitude toward the occurrence of vaccine reactions.