If patients want to get pregnant, they should go to the hospital to make sure that the insulin resistance has been controlled and stabilized before preparing for pregnancy, and the exact time varies from person to person. Taking metformin can only be used to treat insulin resistance, not infertility. Insulin resistance refers to the inability of insulin to effectively promote glucose uptake by peripheral tissues or inhibit hepatic glucose output, and is prevalent in a variety of metabolism-related diseases. Discontinuation of metformin needs to be done under the supervision of a physician, and the control of the condition should be adequately assessed for stability prior to pregnancy preparation. It is important to note that metformin is contraindicated in those who are allergic to the drug, those with kidney disease, and those with acute alcoholism, and patients may experience adverse reactions such as nausea, vomiting, and diarrhea after taking the drug. It is recommended that patients with insulin resistance who wish to prepare for pregnancy should do so when their condition is cured or better, under the advice of a doctor, and the medication should also be used under the guidance of a doctor.