Closed antibody negative is not difficult to treat and needs to be treated in a regular hospital. If the closed antibody is negative, it may cause infertility or spontaneous abortion. For the treatment of antibody-negative, you can choose spousal leukocyte immunotherapy. After systematic treatment, most people can get pregnant normally. There are many reasons for miscarriage after pregnancy. If it is determined that it is caused by closed antibody negativity, spousal leukocyte immunotherapy can be used. If the miscarriage is caused by other reasons, such as luteal insufficiency, symptomatic treatment is needed. If you are planning to get pregnant, take folic acid to prepare for pregnancy along with active treatment. Taking folic acid during preparation for pregnancy is good for eugenics. During the preparation for pregnancy, you should relax and not be too nervous, and improve all the preconception tests.