The causes of hand pain and swelling at night include sleeping position factor, cervical spondylosis, soft tissue injury and so on. 1. Sleeping position factor: due to incorrect sleeping position at night or sleeping to keep a posture, causing one side of the blood circulation deterioration, triggering the patient’s side of the limb numbness, swelling, pain and other symptoms. 2. Cervical spondylosis: If the patient suffers from cervical spondylosis, such as cervical osteophytes, cervical intervertebral disc herniation, cervical ligament hypertrophy and other diseases, it will stimulate the peripheral nerve tissues, which will lead to the patient’s hands to appear numbness, pain, soreness, swelling and other symptoms. 3. Soft tissue injury: due to external factors such as falling, extrusion, friction and other external factors, resulting in soft tissue injury to the hand, to the night time, the soft tissue injury revealed, manifested as swelling, redness, numbness and so on in the hand. There are many reasons for hand pain and swelling at night, it is recommended that patients go to the hospital in a timely manner to improve the relevant examination, to clarify the cause of the disease, and comply with the doctor’s instructions for treatment.