The causes of chest pain at night mainly include the following: first, it is considered to be caused by the body’s cardiovascular system diseases, mostly due to the usual myocardial ischemia, exertional angina and other cardiac system disorders, plus at night due to the body’s sympathetic excitation, which in turn causes an increase in myocardial blood supply or emotional excitement, can lead to chest pain. For this cause of chest pain, it is necessary to apply drugs to improve the blood supply to the heart muscle. In addition, regular review of ECG and cardiac ultrasound is needed to observe changes in the condition. Secondly, it is considered to be due to respiratory system diseases of the organism, including spontaneous pneumothorax, acute and chronic pleurisy, and ruptured pulmonary blisters, which cause respiratory system diseases and cause chest pain, mostly accompanied by respiratory symptoms such as coughing and suffocating wheezing, which can mostly be significantly relieved by applying drugs to improve breathing and ventilation as well as antispasmodic and wheezing. Then, it is considered to be caused by intercostal nerve pain, the typical manifestation of intercostal nerve pain is obvious pain at night, which can be significantly relieved by taking nerve-nourishing drugs. If there is a combination of some symptoms such as reflux and acid reflux, reflux esophagitis, peptic ulcer and other diseases should be considered.