Gastric disease quadruple therapy should refer to the killing of Helicobacter pylori, the treatment of dyspepsia as well as ulcers and other commonly used quadruple drugs, including acid-suppressing drugs, bismuth preparations and two kinds of antibiotics, the most common adverse reaction is the emergence of an allergic reaction, because the antibiotics may lead to allergic rashes, in addition to the use of acid-suppressing drugs part of the patient can also be allergic to the emergence of allergies, headache, panic and other symptoms. Also pay attention to the adverse reactions of antibiotics, such as metronidazole will have more obvious gastrointestinal tract stimulation, the patient will be nausea, vomiting, epigastric discomfort, clarithromycin can also lead to palpitations, panic and other discomforts, in addition to furazolidone, tetracycline and other antibiotics, as well as levofloxacin, but also to pay attention to neurological and other adverse symptoms. Of course all antibiotics when taking, first ask the patient whether the liver and kidney function is normal, these drugs may cause abnormal liver and kidney function. Antibiotics when taking quadruple drugs may also lead to an imbalance of bacteria in the intestines, resulting in diarrhea, constipation and other disorders of bowel function, and pectin bismuth will lead to a change in the color of the stool after taking it, which should also be paid attention to. These are the common adverse effects of the quadruple drug method for stomach problems, but most quadruple treatments for stomach problems are safe and effective.