Taking Azithromycin for a long period of time may lead to drug resistance, thus affecting the treatment effect of the disease. Some patients are also susceptible to adverse reactions such as indigestion and headache with long-term use of the drug. Azithromycin belongs to antibacterial drugs, can be used to treat infectious diseases caused by sensitive bacteria, such as Haemophilus influenzae, Streptococcus pyogenes, Streptococcus pneumoniae and other causes of bronchitis, pneumonia, acute otitis media and so on. If patients take azithromycin on their own for a long time, it may induce the body to develop drug resistance, thus affecting the antibacterial effect and the recovery of health. Some patients taking Azithromycin may experience adverse reactions such as indigestion, headache, nausea, vomiting and skin rash. If the drug is used for a long period of time, the above adverse reactions may persist and may even induce liver function impairment, which should be taken seriously. If the patient is allergic to azithromycin, erythromycin, other macrolides, the drug is contraindicated. It is also contraindicated in those who have a history of cholestatic jaundice or hepatic insufficiency after previous application of azithromycin. It is recommended that patients follow the doctor’s instructions to apply azithromycin, do not self-medicate, and pay attention to regular medical review during the use of medication.