Swelling and pain in ankle may be related to ankle sprain, arthritis, gout, etc. Patients can relieve the symptoms through general treatment, medication and physical therapy. 1. Ankle sprain: Ankle sprain may cause pain and swelling, patients can rest properly at the beginning, cold compresses and massage on the affected area to relieve the symptoms of swelling and pain. For more serious pain patients can take diclofenac sodium, ibuprofen and other drugs under the guidance of the doctor for analgesic and anti-inflammatory treatment. 2. Arthritis: for arthritis caused by joint swelling and pain in patients, under the guidance of the doctor to take non-steroidal anti-inflammatory painkillers, such as aspirin, ibuprofen, celecoxib, etc. for treatment, the patient can also be through the medicated baths, massages, body therapy and other ways to alleviate the condition. 3. Gout: For patients with gout-induced ankle swelling and pain, non-steroidal anti-inflammatory drugs, such as indomethacin, diclofenac, etoricoxib, etc., can be taken as prescribed by the doctor; drugs to promote the excretion of uric acid, such as phenylbromarone, probenecid, and so on for treatment in order to alleviate the condition. It is recommended that patients strictly follow the doctor’s instructions for the correct use of medication, do not change the dose of drugs or private abuse of drugs, patients need to pay attention to rest during the treatment period, avoid strenuous activities, but also pay attention to monitoring the condition, once the condition worsens need to consult a doctor in a timely manner.