Modern life is fast-paced, work pressure, many friends may need to work overtime, overload work. The disruption of the life pattern will more or less exhaust the stomach with some problems. The common means of examination for stomach discomfort are upper abdominal ultrasound or gastroscopy or upper gastrointestinal barium meal examination. The reason why some people are afraid to go to the hospital is in many cases the unfamiliarity and fear of the unknown environment and examination methods. Ultrasound of the upper abdomen and barium meal of the upper gastrointestinal tract may be acceptable to many people, especially the ultrasound of the upper abdomen, which is included in many units of the usual physical examination program, but gastroscopy is a matter of opinion. Many people are afraid to do gastroscopy. So, is gastroscopy painful? Who needs a gastroscopy? What do I need to be aware of when having a gastroscopy? Out of many people’s lack of understanding of gastroscopy, I would like to introduce the process here. Gastroscopy is the use of a diameter of about 1M endoscope into the mouth of the subject, in order to observe the state of the mucosa of the esophagus, stomach, duodenal bulb, descending, and, if necessary, histopathological examination and cytological examination of the lesion site. Some medical institutions routinely perform Hp examinations at the same time. In general, the entire examination takes about 10 minutes. Gastroscopy is diagnostically reliable, safe, and very technically mature, and is suitable for examining mucosal lesions in the esophagus, stomach, and duodenum bulb and descending parts. On the basis of this, some new examination techniques have emerged, such as ultra-fine transnasal gastroscopy, dye magnification endoscopy, ultrasound endoscopy, and anesthesia endoscopy. Gastroscopy is needed for people with the following symptoms: upper gastrointestinal symptoms, including upper abdominal distension and pain, burning sensation or heartburn in the upper abdomen, acid reflux, swallowing discomfort or choking, early satiety, belching, eructation, loss of appetite with weight loss, especially those with anemia or upper gastrointestinal bleeding (mainly vomiting blood and black stool), and screening for high-risk groups (esophageal cancer and stomach cancer high incidence areas). What should be noted? Note: It is better to eat some easily digestible food the day before the examination and not to eat late night snacks, and to fast from food and water for 8 hours before the examination. During the examination, try not to be nervous and vomit, do not breathe in through the nose, breathe out through the mouth, and breathe smoothly and slowly. Generally, under the guidance of an experienced doctor and with good cooperation from the examinee, you can do nothing painful. If it is the first time you are examined and you are overly nervous or really can not cooperate after repeated attempts to complete the examination, the examination can be done under anesthesia and sedation to minimize pain. Alternatively, you may consider an ultra-fine transnasal gastroscopy. This gastroscope has an outside diameter of 5.9 mm and is inserted through the nasal cavity with little discomfort. Patients can sit for the gastroscopy, watch the monitor and ask questions of the doctor, making it more user-friendly for patients who are anxious to understand their condition. Some patients may experience pain or foreign body sensation in the throat after the examination, which may be relieved or disappear within a few days. If there is no significant discomfort after the examination, you can eat and drink normally after 1 hour. It is worth mentioning that some conditions require biopsy patients, after the examination should eat thin rice, soup, the temperature to room temperature or slightly warm, avoid eating raw, cold, hot, hard and irritating food. Smoking, spilling, drinking strong tea and coffee may induce bleeding on the trabecular surface. If black stool appears, please seek medical follow-up promptly. There are 2 main common gastroscopy findings, chronic superficial gastritis and chronic atrophic gastritis. Chronic superficial gastritis, also known as chronic non-atrophic gastritis, does not require special treatment and can be treated symptomatically if there is discomfort; chronic atrophic gastritis, an age-related degenerative change, usually occurs after the age of 40 and is treated in the same way as chronic superficial gastritis as long as there is no heterogeneous hyperplasia or moderate to severe atypical hyperplasia. If atrophy occurs before the age of 40 or excessive atrophy at an age when atrophy should occur, and heterogeneous hyperplasia or moderate or severe atypical hyperplasia or marked intestinal epithelial hyperplasia is present, the possibility of cancer at the atrophic site needs to be guarded. In addition, other gastroscopic findings, such as: esophagitis, Hp infection, acute gastric mucosal lesions, erosive or bile reflux gastritis, ulcer disease, upper gastrointestinal polyps or masses, etc. must be treated formally by specialists. Gastroscopy results are best treated with appropriate medication after consultation with a specialist.