When a patient gets up from a nap with eye pain, it may be caused by physiological factors such as eye fatigue, or it may be caused by diseases such as conjunctivitis and blepharitis. 1. Physiological factors: eye fatigue caused by gazing at the cell phone or computer screen for too long before going to bed, or staying up too late can lead to eye pain while sleeping, which can be relieved by applying hot compresses and resting, and generally does not require special treatment. 2. Conjunctivitis: poor eye hygiene leads to bacterial infection of the patient’s conjunctiva, causing an inflammatory reaction, inflammatory stimuli can lead to eye pain, photophobia, tearing and other symptoms, can be in a sleep up with eye pain. 3. Blepharitis: Blepharitis refers to purulent inflammation of the eyelid glands. Under the stimulation of inflammation, the patient may experience redness, swelling, heat and pain in the eyes, which may cause eye pain when he/she gets up from sleep. It is recommended that patients with significant eye pain after a nap should seek medical attention in a timely manner to assess their condition and follow the doctor’s instructions for treatment.