Causes of high total bilirubin include hemolytic jaundice, liver disease, obstructive jaundice, and other causes. Hazards such as liver and kidney function, central nervous system, and skin may occur. 1. Hemolytic jaundice: If you suffer from hemolytic diseases such as serosanguineous disease, spherocytosis, Mediterranean anemia, etc., it will easily lead to the destruction of red blood cells, which will be retained in the blood beyond the liver’s transforming ability, resulting in the elevation of total bilirubin. 2. Hepatocellular jaundice: when the patient suffers from autoimmune hepatitis, viral hepatitis, drug-induced liver injury, jaundice hepatitis and other diseases, it will easily lead to bilirubin metabolism abnormality, so that the bile discharge obstacles, resulting in high total bilirubin phenomenon. 3. Obstructive jaundice: If you suffer from bile duct stones, cholecystitis, pancreatic cancer and other diseases, it may lead to bile in the bile duct can not be discharged, resulting in obstructive jaundice and high total bilirubin. High total bilirubin may damage liver and kidney function, biliary stasis may further cause biliary cirrhosis, damage to the central nervous system, and biliary stasis may lead to yellowing and itching of the skin all over the body. When you have high total bilirubin, you should go to the hospital immediately for further examination, and your doctor will give you the right treatment according to the examination results.