Taking metronidazole and ornidazole for a toothache has similar results and is not significantly better or worse. However, there are many causes of toothache, not all toothache need to take antibacterial drugs. Metronidazole and ornidazole are anti-anaerobic infections belonging to anti-inflammatory drugs, the efficacy of the two drugs is not very different, clinically there are anaerobic infections of toothache can be under the guidance of the doctor to use these two drugs. If the toothache is caused by other factors, taking these two drugs may not achieve a better effect. If the toothache is caused by diseases such as pulpitis or periapical periodontitis, the medication may not be effective and root canal treatment is needed. Others, such as trigeminal neuralgia, do not require the use of antibacterial drugs. If you have a toothache, you should consult your doctor to find out the cause of the toothache and receive treatment. Metronidazole or Ornidazole should be used under doctor’s supervision.