Diabetic ketoacidosis, diabetes mellitus patients in the role of various triggers in the body insulin secretion is insufficient, blood glucose resistance hormone inappropriately elevated, resulting in hyperglycemia, electrolyte metabolism disorders, metabolic acidosis and other pathological changes in the syndrome. Patients who may have or have had ketoacidosis with coma should be closely observed for vital signs and changes in condition, and fluid intake and output should be recorded. Replenishment of fluids is the key link in the rescue of ketoacidosis in order to rapidly replenish blood volume, improve peripheral circulation and renal function, fluid infusion should be completed within the specified time, immediately open two venous accesses to ensure the infusion of fluids and insulin. Patients need absolute bed rest, pay attention to warmth, give low-flow continuous oxygen, strengthen life care, prevent pressure sores and secondary infections, according to coma care. Small doses of insulin should be given for continuous treatment, and specimens need to be taken every 1-2 hours to send for urine glucose, urine ketone, blood glucose, blood ketone, blood potassium, blood sodium, and carbon dioxide binding capacity during the infusion and insulin treatment. Treatment also involves prevention of triggers and management of complications, including shock, infection, heart failure, arrhythmia, renal failure, cerebral edema, and acute gastric dilatation.