Esophagogastric fundus varices are thickened, tortuous and dilated veins in the esophagus and fundus of the stomach. In the early stage, they are like earthworms, and as the disease progresses, they gradually thicken to become nodular and bead-like. The etiology is mainly caused by portal hypertension, which is common in the advanced stage of liver cirrhosis and some pancreatitis diseases. Patients may present systemic symptoms, such as fatigue, emaciation, dark color, jaundice, oliguria, lower limb edema. Digestive symptoms such as loss of appetite, abdominal distension and diarrhea; bleeding tendency and anemia, hypoproteinemia, spider nevus, liver palms and so on. The main treatments are drug treatment, surgical treatment and endoscopic treatment: 1.Drug treatment: (1) Diuretics: reduce blood volume and visceral blood flow, reduce portal pressure, commonly used drugs are spironolactone, hydrochlorothiazide and so on. (2) Proton pump inhibitors: reduce gastric acid secretion, favor coagulation, commonly used omeprazole, esomeprazole and so on. (3) Growth inhibitors and other similar drugs: reduce portal vein blood flow, thereby reducing portal vein pressure, commonly used growth inhibitors, octreotide, etc. (2) Surgical treatment, according to the condition of the patient, choose to cut off the flow, shunt surgery, splenectomy, liver transplantation, etc. 3. Endoscopic treatment, including ligation and sclerotherapy. If you are diagnosed with esophagogastric fundal varices, you need to go to a regular hospital, complete the relevant examinations, and follow the doctor’s instructions to standardize the treatment, so as not to delay the condition.