Lipoic acid and methylcobalamin can generally be taken together. Lipoic acid and methylcobalamin belong to the same group of B vitamins, there is no contraindication to their biological effects and pharmacokinetics, but they are the same class of drugs, there may be duplication of medication, need to consult a doctor. Lipoic acid is indicated for the treatment of diabetic peripheral neuropathy, adverse reactions include gastrointestinal reactions, allergy, altered sense of taste, blood glucose lowering, etc. It is contraindicated in people who are allergic to the drug. Lipoic acid can reduce blood glucose concentration, should pay attention to monitoring blood glucose changes during the drug. Methylcobalamin is adapted to the treatment of various types of peripheral neuropathy, adverse reactions include loss of appetite, nausea, vomiting, diarrhea, allergies, etc. It is prohibited for those who are allergic to the drug, and workers engaged in the mercury and its compounds should not take large amounts of this product for a long time. It is recommended that patients should seek medical advice if they are unwell and use the drug under the guidance of a physician.