Once typhoid fever is diagnosed, it should be isolated and treated with antimicrobial therapy, in addition to preventing intestinal bleeding and perforation. Typhoid fever is an acute intestinal infectious disease caused by Salmonella typhi, because the disease is contagious, so it has been diagnosed, it should be isolated and treated, and at the same time the use of oxfloxacin, azithromycin, cefepime and other medications for antimicrobial treatment, and if the patient develops intestinal perforation of the complications of the patient, then it is necessary to be treated by surgery. Daily attention should be paid to wash hands, avoid taking untreated water, stay away from typhoid infected areas, when taking food, make sure that the food is sufficiently heated to eliminate germs, in addition to typhoid fever can be prevented by typhoid fever vaccine, the use of medication please follow the doctor’s instructions.