Severe hyperpigmentation of the face can be seen in pigmented disorders such as heterochromia, melasma, freckles and nevus of Ota. Pharmacogenic skin pigmentation should also be considered, such as taking certain antibacterial drugs, antimalarial drugs, antipsychotic drugs, circulatory drugs, immunosuppressants, hormones, etc. In addition, staying up late, eating spicy and greasy food, prolonged sun exposure, tattoos, exposure to heavy metals and pollution may also lead to hyperpigmentation.