Small intestinal mesenchymal tumor with liver metastasis is generally more serious, indicating a later stage of the disease, a more severe condition, and more difficult to treat. Small intestinal mesenchymal tumor with liver metastasis becomes secondary liver cancer, which cannot be resected by surgery, and may have symptoms such as pain in the liver area, swelling of the lower limbs, etc. It may also have defecation disorders, with symptoms such as constipation, blood in the stool, and anal discomfort, and generally can only be treated by radiotherapy and targeted drugs, such as imatinib, and other treatments. Suitable treatments should be chosen according to the patient’s physical condition and illness, so as to reduce the pain of the disease and prolong the survival period. During the onset of the disease, pay more attention to rest, do not eat high-fat, high-cholesterol food, no smoking and alcohol, maintain a good state of mind, do not have too much pressure, and cooperate with the doctor to carry out the treatment, in order to prevent the disease from deteriorating.