Whether or not chemotherapy is needed after neoadjuvant chemotherapy depends on the type of cancer and the treatment plan determined for that cancer. Chemotherapy is usually required after neoadjuvant chemotherapy and it is recommended that you consult your doctor for more information. Neoadjuvant chemotherapy is a kind of systemic chemotherapy for locally progressive tumors without metastasis before local treatments (e.g., surgery or radiotherapy) are carried out, aiming at shrinking the cancerous tissues and killing invisible metastatic cancer cells as early as possible, so as to lay a good foundation for subsequent treatments such as surgery and radiotherapy. Neoadjuvant chemotherapy can reduce the size of the tumor, lower the clinical stage, increase the rate of surgical resection, and can improve the rate of organ preservation in cancers such as breast cancer, osteosarcoma and rectal cancer. For specific treatment plan, it is necessary to consult professional physician’s opinion.