Common causes of large skin nodules include dermatofibromas, acne, sebaceous cysts, plantar warts, etc. Symptomatic treatment is needed, including medication and surgery to remove them. 1. Dermatofibroma: large nodules formed due to overgrowth of skin fibroblasts, which can be treated with surgical procedures such as fibroidectomy. 2. Acne: Severe acne can develop large nodules that can be treated with medications such as tazarotene. 3. Sebaceous cysts: If the large nodules are sebaceous cysts, cystectomy may be necessary. 4. Plantar warts: Because the human papilloma virus infection of the human body will trigger the proliferation of tissues, so the appearance of large hard pimples, can be injected into the lesions of bleomycin and other methods of treatment. The phenomenon of large hard skin nodules may also be other causes, please consult a doctor in time, standardized treatment under the guidance of the doctor.