When there is thrombosis or embolism in the arteries of the lower limbs, it can lead to ischemia in the arteries of the lower limbs and lead to symptoms of fatigue and weakness when walking, and it is necessary to check the angiography and angiography of the arteries for diagnosis and early treatment. Second, lower limb vein disease, when the lower limbs have phlebitis or varicose veins, can also have walking leg fatigue, weakness symptoms, can be accompanied by lower limb swelling, especially when standing for a long time or walking for a long time symptoms are more obvious, this time to early examination, check the lower limb vascular ultrasound to diagnose. Third, kidney deficiency, when the kidney deficiency can also have the symptoms of leg strain when walking, can be accompanied by lumbar acidity and fatigue symptoms, then we should go to the Chinese medicine department to take a pulse diagnosis, early oral kidney medicine treatment.