Waking up with a bitter mouth and saliva with a lot of blood, may be traumatic blood blisters, gastrointestinal bleeding and other conditions, need to analyze the specific problem. 1.traumatic blood blisters: because of the blood blister stimulation will appear pain, so part of the population dare not swallow saliva, and then manifested as waking up saliva. When the blood blister rupture, due to the bacteria and blood mixing, then there will be bitter mouth, saliva with blood performance. 2. Gastrointestinal bleeding: part of the population will appear blood reflux to the oral cavity, blood stimulation of the oral cavity localization, will cause increased salivary secretion, at the same time there may also be bile mixed together to cause bitter mouth, and ultimately manifested in the waking up of bitter mouth and saliva with blood performance. Because of the many causes of waking up with bitter saliva and blood, it is recommended to go to a regular hospital in time, with the help of a doctor to clarify the diagnosis, and follow the doctor’s instructions for treatment.