According to the current evidence-based medicine, there is no drug that can efficiently treat knee osteomalacia, but anti-inflammatory and pain relieving drugs such as Celecoxib, chondroprotective agents such as Glucosamine, anti-osteoporosis and blood circulation and blood stasis activating drugs etc. can be used. 1. Anti-inflammatory painkillers: oral celecoxib, diclofenac sodium tablets or topical diclofenac diethylamide and other drugs, these drugs mainly play a role in inhibiting inflammatory reactions, pain, swelling and so on. 2. Cartilage protection drugs: common glucosamine, chondroitin sulfate, etc., it is found that these drugs can slow down the process of cartilage degeneration and alleviate the progress of the disease, in addition to the joint cavity injection of sodium vitrate is also conducive to the protection of cartilage. 3. Anti-osteoporosis and blood circulation and blood stasis medicines: such as anti-osteoporosis pills, Xianling Bone Capsules, blood circulation and analgesic cream and other medicines, which can help alleviate the patient’s symptoms such as swelling, pain and so on. Knee osteomalacia not only need medication, it is recommended that the patient timely hospital consultation, improve the relevant examination, clear the degree of knee joint damage, and then carry out further comprehensive treatment. The use of drugs need to follow the doctor’s instructions.