Hyperglobulinemia occurs in dry syndrome.
Dry syndrome is a diffuse connective tissue disease characterized by invasion of exocrine glands such as lacrimal and salivary glands, as well as abnormal proliferation of B-lymphocytes and infiltration of tissue lymphocytes. The main clinical manifestations are dry keratitis, oral xerosis and rampant dental caries, and even involvement of other organs.
As the disease progresses, the polyclonal increase of lgG in the blood leads to the development of hyperglobulinemia, and in a few patients, macroglobulinemia can occur.
Clinically, if there is no internal organ damage, it is recommended to carry out alternative, symptomatic treatment first, such as correcting hypokalemia, intravenous potassium supplementation, and switching to oral potassium salt tablets such as potassium chloride tablets after stabilization; artificial tears and artificial saliva to reduce local symptoms. If there is internal organ damage, immunosuppressive therapy, such as anti-CD20 monoclonal antibody rituximab.
Patients are advised to go to the hospital in time to avoid delay.