GERD symptoms are similar to coronary heart disease in terms of pain. Severe GERD will present with symptoms such as severe epigastric pain, radiating pain in the back of the shoulder, and other symptoms similar to angina pectoris of coronary heart disease. Coronary angina is generally less than 30 minutes of pain, the anterior region of the heart/poststernal (left) crushing pain, accompanied by a sense of dying, sweating and other symptoms, oral nitroglycerin can be relieved, and most of the attacks of coronary heart disease has a history of hypertension, hyperlipidemia and other medical conditions. Gastroesophageal reflux disease is often painful for more than 30 minutes to 1 hour, usually burning pain, severe stabbing pain, mostly in the hour after meals, easy to appear when lying down. Symptoms can be relieved by oral acid-suppressing drugs (omeprazole, etc.). Although there are a few similarities between the two in terms of pain, it is not difficult to differentiate between the two by history, symptoms, signs, and laboratory imaging. In case of severe chest/abdominal pain, medical attention should be sought to avoid delay.