Step: Take 20ml of venous blood from the husband, separate and extract lymphocytes with lymphocyte separation solution, wash twice with saline, add 1ml of saline and dilute with γ-irradiation, inoculate 6-8 points in the wife’s front buttock medially in an intradermal radial pattern, the number of lymphocytes is 2-2.5×10(7)/ml. 24-72 hours after the injection, local erythematous nodules with diameters ranging from 3 to 10mm appear, Four injections were given at 3-week intervals per course of treatment. Pregnancy was encouraged after the first course of treatment, and two more injections were given after pregnancy. For patients who still have symptoms of pre-eclampsia after 2 treatments during pregnancy, 2 to 4 additional treatments will be given. Principle: From the modern viewpoint of reproductive immunity, primary habitual abortion may be due to immune hyporesponsiveness of the patient to the paternal antigen of the embryo. Based on this theory domestic and foreign scholars use immunotherapy of the mother with leukocytes and lymphocytes of the husband or unrelated individuals. The aim is to induce maternal immune responsiveness to embryonic antigens or related allogeneic antigens. Pregnancy is a successful semi-allogeneic transfer process in which the husband’s HLA antigens carried by the embryo stimulate the maternal immune system and produce a class of IgG-type antibodies, called blocking antibodies, which are present in the serum of pregnant women and inhibit lymphocytotoxic activity against the husband’s HLA-specific antibodies, and inhibit rejection of the allograft. In women with unexplained habitual abortion, this antibody is not present in the serum but can be obtained by injection of the husband’s lymphocytes. The relationship between the skin reaction at the injection site and the efficacy of the treatment, the severity of the skin reaction can be judged as one of the very useful observation indicators of the effect of immunotherapy, the skin reaction after the first injection is heavy, i.e., 24-48 hours of local redness and hard nodules of 3-10 mm in diameter, and the prognosis of pregnancy is good if the skin reaction gradually decreases after several injections. The efficacy of immunotherapy in the treatment of habitual abortion is positive, safe and easy.