Chronic granulocytic leukemia encephalopathy indicates that leukemia cells have infiltrated the brain, and the main treatment is chemotherapy plus targeted treatment. 1. The occurrence of cerebral infiltration indicates that chronic granulocytic leukemia has progressed to the acute stage, which can be treated with chemotherapy with dasatinib. If there is a suitable donor after the disease is controlled, allogeneic hematopoietic stem cell transplantation should be carried out as early as possible. If there is no donor, the disease can be treated as acute leukemia with cranial plus total spinal cord radiotherapy. 2. Cerebral infiltration occurs, which can be manifested as headache, nausea and vomiting, vomiting in the form of jet, and mannitol can be given to lower the cranial pressure for targeted treatment. Chronic granulocytic leukemia encephalopathy is recommended to be hospitalized under the guidance of a physician to receive treatment, it is recommended that family members give more company.