Oxyfloxacin eye drops and levofloxacin hydrochloride are both quinolone antibacterial drugs, mainly in the composition, antibacterial effect of the difference. In terms of composition, the main ingredient of ofloxacin eye drops is ofloxacin, while the main ingredient of levofloxacin is the levorotatory isomer of of ofloxacin, which is essentially the same, but there is a certain difference in activity. In terms of antibacterial effect, the antibacterial activity of levofloxacin is two times of that of of ofloxacin, and levofloxacin is characterized by wider antibacterial spectrum and stronger antibacterial effect. Both are fluoroquinolones, and some patients may experience adverse reactions such as eyelid swelling, conjunctival congestion, and itching sensation after using these drugs. Patients also need to avoid long-term use, so as to prevent the body from developing drug resistance, and those who are allergic to ofloxacin and levofloxacin are prohibited from using them. Patients are advised to use ofloxacin eye drops or levofloxacin hydrochloride as prescribed by the doctor and not to use it without authorization to avoid adverse reactions.