There is no best antihypertensive drug, only the most suitable drug for oneself, because the principle of applying antihypertensive drugs is most importantly individualized treatment, to choose different drugs according to different conditions. No antihypertensive drug is suitable for all patients, and there is no best antihypertensive drug. Antihypertensive drugs are divided into several major categories, including angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, beta-blockers, calcium antagonists and diuretics. Mild-to-moderate hypertension or younger patients, as well as patients with diabetes, are candidates for the various Prilosec and various sartans. beta-blockers are suitable for patients with hypertension combined with increased heart rate and heart failure. Older hypertensive patients, especially those with coronary artery disease, are candidates for calcium antagonists, i.e., various diphenhydramine analogs. If the elderly stubbornly increased systolic blood pressure, pulse pressure difference is relatively large, can be appropriate combined with diuretics to lower blood pressure treatment.