Diarrhea and cold hands and feet are associated with dehydration and water electrolyte disorders, and are commonly seen in patients with rotavirus infections and acute gastroenteritis. When diarrhea occurs, the intestinal system is not only unable to absorb water from food, but also loses a large amount of water from the body along with food residue because the intestinal system is under hypertonic pressure. Many people suffer from diarrhea due to dehydration, water electrolyte disorders, and insufficient blood circulation in the extremities, resulting in cold hands and feet and dry skin, etc. Oral rehydration salts can be used to replenish the lost water in the body and alleviate the condition. When rotavirus infection occurs in the human body, diarrhea, cold hands and feet will occur because rotavirus can damage the intestinal function. Inflammation exists in the patient’s digestive system during an acute gastroenteritis attack, so there will be nausea, vomiting, abdominal pain, diarrhea, which will also lead to water-electrolyte disorders and cold hands and feet.