Generally speaking, an occasional use of Kesler has no effect. Kesler is an anal suppository preparation used in the anus to reach the rectum through the anus, thus stimulating the rectal wall to defecate reflexively. Occasional use of corkscrew does not have a great effect, but do not use it for a long time to avoid side effects. Frequent use of Kefir to promote defecation is likely to cause the patient’s dependence and the formation of drug resistance, resulting in the patient’s rectal sensitivity is weakened, defecation can only rely on Kefir to carry out. In addition, the main ingredient of Kefir is glycerin, which is highly absorbent and will absorb water from the rectal wall when used, causing dryness of the intestinal wall in the long term and the formation of habitual constipation. The above medications should be used under the guidance of a doctor, avoid self-medication.