Gallbladder stone pain in the middle of the night can be relieved by changing body position, fasting and water fasting, medication and other methods. 1. Changing body position: gallbladder stone pain in the middle of the night may be caused by the movement of the stone due to the change of body position to compress the nerves and cause pain, you can try to change the body position can relieve the pain. 2. Fasting and water fasting: Intake of food and water will make the gallbladder contract and aggravate the pain, so you can take fasting and water fasting to relieve the symptoms. 3. Medication: Pantoprazole and scopolamine can be used to relieve symptoms. The use of pantoprazole, scopolamine, ibuprofen and other acid suppression, antispasmodic, pain treatment. If by using the above ways, the symptoms are not relieved, should promptly consult a doctor to clarify the cause of the disease, under the guidance of the doctor for treatment, follow the doctor’s prescription medication.