Itchy scrotum while sleeping may be caused by pubic lice, scabies, scrotal eczema and other diseases. 1. Pubic lice: Pubic lice mainly settle in the pubic hair, due to the bite of the scrotum skin can cause insect bite dermatitis, especially at night itching symptoms are more obvious. 2. Scabies: If there is scabies on the scrotum skin, the itching of the scrotum skin is more obvious at night because the scabies bug likes to move at night. 3. Scrotal eczema: scrotal eczema can cause scrotal skin itching, vesicles, oozing, and if it develops into chronic scrotal eczema, the itching will be more pronounced, the scrotal skin is thickened, and there will be scales. Itching of the scrotum while sleeping may also be caused by other factors. If the symptoms persist for a long time, it is recommended that the patient go to a regular hospital in time for treatment and strive for early recovery.