Fungal infections of the skin disease is generally due to not pay attention to cleanliness and hygiene, sharing personal items with patients and other infections, more difficult to treat, the reason is that poor hygiene habits will lead to recurrent attacks, need to be treated with medication with life hygiene habits to achieve better therapeutic effect. 1. Commonly used drugs are itraconazole, terbinafine, clotrimazole cream and so on. Itraconazole: used for the treatment of systemic fungal diseases, such as skin fungal disease, vulvovaginal candidiasis, nail fungal disease, fungal disease keratitis and so on. Adverse reactions include headache, nausea, abdominal pain, rhinitis, leukopenia, etc. It is contraindicated for those who are allergic to this product. Terbinafine: used to inhibit the growth and reproduction of fungi, suitable for fungal ringworm, tinea pedis, etc. Adverse reactions include rash, itching, etc., prohibited for those who are allergic to this product. Clotrimazole cream: used to inhibit the growth of fungi, relieve itching and vesicles and other symptoms, suitable for tinea capitis, ringworm and other treatments. Adverse reactions include erythema and so on. 2. The difficulty in treating this disease is that not paying attention to hygiene will lead to recurrence, so that the condition is prolonged and repeated. Should follow the doctor’s instructions to use drugs at the same time pay attention to keep the affected area dry, clean and hygienic, do not share slippers, bath towels and other supplies. If the diagnosis of fungal infection skin disease, it is recommended to consult a doctor for treatment, follow the doctor’s prescription medication, pay attention to daily hygiene.