In the prevention and treatment of coronary heart disease, it is necessary to adopt corresponding prevention and treatment means according to the physiological and pathological differences between men and women, so as to achieve the best treatment and prevention strategy. In recent years, the incidence of coronary heart disease has been on the rise, and it is one of the major heart diseases that cause death in our country. A large number of epidemiological studies have found that the differences in clinical characteristics, risk factors, degree and extent of lesions, etc. between male and female patients with coronary heart disease are becoming more and more prominent. In addition to the same risk factors of coronary heart disease in women as in men, such as overweight, dyslipidemia, hypertension, diabetes mellitus, smoking, etc., the more important characteristic of women is related to the decline of endogenous estrogen level after menopause. And estrogen levels decline in a stepwise fashion with age. Research statistics at the age of 50 years old, the secretion level of estrogen is about 1/2 of that of the young, at the age of 60 years old, the secretion level of estrogen is only 1/4 of that of the young; and at the age of 80 years old, the estrogen is less than 1/5 of that of the young. estrogen is an important vascular protective factor, which has the effect of improving lipid metabolism, preventing endothelial damage, inhibiting platelet aggregation and inhibiting the thickening and hardening of the walls of small arteries. Therefore, when estrogen secretion is reduced, it will lead to lipid metabolism disorders in the body, promote the formation of atherosclerosis, so that the incidence of coronary heart disease is greatly increased, and the speed of coronary artery disease is accelerated. Studies have found that women due to the protective effect of estrogen, so that atherosclerosis is delayed by about 10 years compared with men, so the incidence of coronary heart disease after menopause and mortality rate of women showed a significant upward trend. Therefore, in the prevention and treatment of coronary heart disease should be targeted according to the physiological and pathological differences between men and women to take appropriate means of prevention and treatment, so as to achieve the best treatment and prevention strategy.