As we all know, some cancers can be cured, and even if they can’t be cured, timely treatment can greatly improve the survival rate, but there is a kind of cancer that almost few people can escape from its “clutches”, which is known as “king of cancers” pancreatic cancer. Pancreatic cancer is a malignant tumor of the digestive system with hidden clinical manifestations and rapid onset, with a 5-year survival rate of <1%, which is one of the malignant tumors with the worst prognosis, and is known as "the king of cancer". The early diagnosis rate of pancreatic cancer is not high, the mortality rate of surgery is high, and the cure rate is very low. Pancreatic cancer is divided into pancreatic head cancer, pancreatic body cancer, pancreatic tail cancer and whole pancreas cancer. Pancreatic head cancer accounts for 60~70% of the total. In recent years, the incidence rate of pancreatic cancer increases year by year, and in China, the incidence rate has increased four times in the last 20 years. Pancreatic cancer has a higher degree of malignancy among malignant tumors, and it is one of the top ten malignant tumors that kill the population in China. Different parts of cancer tumors have different symptoms: 1. "Head of pancreas" cancer with abdominal pain, jaundice, epigastric fullness and discomfort; 2. "Tail of pancreas" cancer with abdominal pain, epigastric fullness and discomfort, epigastric mass, lumbar pain; 3. "Whole pancreas" cancer with abdominal pain, epigastric fullness and discomfort, epigastric mass, lumbar pain; 4. "Whole pancreas" cancer with abdominal pain, epigastric fullness and discomfort; 5, Cancer of "whole pancreas" is most common with abdominal pain, epigastric fullness and discomfort, epigastric mass and jaundice. When the first symptom appears and correct diagnosis and treatment cannot be made in time, the symptoms will worsen day by day, and obvious digestive symptoms such as loss of appetite, diarrhea, black stools, vomiting, fatigue, emaciation, etc., and abdominal mass, severe epigastric pain, lumbar and back pain, etc., which are caused by the increased infiltration of pancreatic cancer and compression of peripheral nerves, can also appear. Treatment means Laparoscopy, 125I radioactive particle implantation, argon helium knife and other minimally invasive treatment techniques have become the first choice of patients, which prolongs the survival period of patients and improves the quality of patients' survival at the same time. 1.Laparoscopic palliative surgery for advanced pancreatic cancer Laparoscopy has been increasingly used in the palliative treatment of pancreatic cancer, which not only has the effect of open surgery, but also has the advantages of minimally invasive surgery, no need to open the abdomen, the surgery has little interference to the patients, and the recovery is fast after surgery. 2.125I(iodine)radiation particle implantation 125I (iodine) radiation particle intra-tumor implantation method is not only minimally invasive treatment for the tumor itself, but also continuously effective. Implantation method: The particles can be implanted either intraoperatively or by percutaneous puncture. The number of particles to be implanted and the spacing between particles are determined by a treatment plan based on the results of a CT examination beforehand. The implanted particles can quickly relieve pain, reduce symptoms and prolong life. 3.Arterial Intervention Therapy for Pancreatic Cancer Regional arterial infusion chemotherapy for pancreatic cancer can make chemotherapy drugs more targeted. High concentration of chemotherapy drugs infused into the tumor area can leak out of the blood vessels and stay in the tumor area, so as to increase the concentration of the drugs in the pancreas, duodenum and peri-pancreatic lymph tissues, and achieve the purpose of effectively killing the tumor cells, thus improving the therapeutic effect. After the infusion of anticancer drugs, at the same time the infusion of methylene blue 40mg, can make about 82% of the cases of different degrees of pain relief and disappearance, received a better effect. Methylene blue and anticancer drugs applied at the same time may play a synergistic effect on patients with cancer pain. 4, argon helium knife argon helium knife is the use of cold media (argon) rapid cooling to -140 ℃ and thermal media (helium) rapid thawing and warming to 45 ℃, so that the tumor cells burst death. This kind of heat and cold reversal therapy can completely destroy the tumor lesions. The cooling or heating of the Ar-He knife is limited to the tip of the cold knife, and the shaft of the knife is well insulated, so it will not cause damage to the normal tissue in the path of the puncture. At the same time, after the destruction of tumor cells, the cell antigen enters the bloodstream, which can stimulate the body's immune system to produce cellular immunity and humoral immune response, improving the body's immunity. 5.Nanoknife Nanoknife is a new cutting-edge tumor ablation technology, which forms nanoscale permanent perforations on tumor cells by releasing high-pressure pulses, destroying the intracellular balance and making cells apoptosis rapidly. The advantage of nanoknife is that it kills tumor cells without destroying blood vessels, nerves, bile ducts and bones, so it is especially suitable for pancreatic cancer which is accompanied by vascular invasion and unable to achieve negative margins.