Patients with prolonged constipation will cause a variety of diseases, specifically analyzed as follows: 1, infection: if constipation for a long time, the intestinal mucosa has been attacked by feces, although the intestinal mucosa itself has a barrier effect, but after a long time by the toxin infringement, the barrier effect will be destroyed. Bacteria and toxins in the stool can be absorbed by the body, resulting in chronic infection of the whole body; 2, intestinal cancer: prolonged stimulation of the intestinal mucosa will proliferate, forming intestinal polyps, if 10-20 years of constipation is still not relieved, intestinal polyps will undergo malignant changes, thus becoming intestinal cancer; 3, decreased resistance: affecting the patient’s diet, resulting in generalized lethargy, and the decrease in resistance will cause a variety of diseases.