Chest pain with inhalation may be a physiologic factor, and it may be a symptom of certain diseases, such as intercostal neuritis, pneumothorax, pleurisy, inflammation of lungs, chest wall injury, and so on. 1. Physiological factors: If people who have been inactive for a long time suddenly do a lot of exercise, resulting in excessive muscle tension, the symptom of chest pain with hard breathing may occur. 2. Pathologic factors (1) Intercostal neuritis: Herpes zoster virus infection, as well as spinal degeneration, ankylosing spondylitis and other diseases may lead to intercostal neuritis, which may lead to symptoms of chest pain when breathing hard. (2) Pneumothorax: Pneumothorax is a condition in which air enters the patient’s pleural cavity, leaving the patient’s pleural cavity in a state of pneumoperitoneum, which is mainly characterized by sudden chest pain, followed by chest tightness, dyspnea and other symptoms. (3) Pleurisy: if the patient’s pleura is attacked by pathogenic microorganisms such as bacteria and viruses, pleurisy may occur, and if pleurisy causes the patient to develop pleural effusion, which leads to the symptom that the patient suffers from chest pain when he/she breathes hard. (4) Lung inflammation: If the patient’s lungs are inflamed, such as pneumonia, viruses or bacteria may cause substantial damage to the patient’s lung tissues, which may also lead to symptoms of chest pain with hard breathing. (5) Chest wall injury: If external force causes closed chest wall injury such as fracture or contusion, or open chest wall injury, it may lead to symptoms of chest pain when breathing hard. However, other factors can not be ruled out, it is recommended to consult the doctor in time, and give targeted treatment after the doctor clarifies the cause of the disease.