Numbness of the little toe can be caused by infection, trauma to the lower limbs and feet, pathologic causes such as compression of the spinal cord and nerve roots, or by physiologic factors, such as nerve compression caused by shoes that are too narrow. 1. Infection: accompanied or secondary to various acute and chronic infections, such as measles, influenza, malaria, chicken pox, etc.. Direct infection of peripheral nerves, such as herpes zoster, leprosy, etc., may cause symptoms such as numbness of the little toe. 2. Lower limb and foot trauma: symptoms of numbness in little toes may be related to tibiofibular fracture, ankle fracture, plantar soft tissue injury and other causes. 3. Spinal cord and nerve root compression: due to lumbar spinal stenosis, lumbar disc herniation, lumbar spine tumor and other diseases, resulting in spinal cord and nerve root compression, the phenomenon of numbness of little toes. 4. Physiological factors: such as small shoes or prolonged weight-bearing, at this time there will also be numbness of the little toes, replacement of loose shoes or relaxation of the feet, the symptoms can be relieved. Numbness of the little toes may also have other reasons, if the exclusion of physiological factors still feel numbness of the little toes, it is recommended to go to the regular hospital in a timely manner to improve the relevant examinations, to clarify the cause of the disease, under the guidance of the doctor to carry out targeted treatment or treatment.